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The Drug Discovery World Podcast
DDW Highlights: 19 December 2023
Dec 19, 2023
This podcast highlights key stories from the drug discovery world, focusing on haematology. Topics include real-world evidence on CAR-T therapies in blood cancers, new data for myeloma and lymphoma treatments, clinical trial results for lymphoma and pediatric acute lymphoblastic leukemia therapies, and a collaboration for manufacturing lentiviral vectors for CAR-P-A-L-L clinical trial.
12:25
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Quick takeaways
- Bristol Myers Squibb obtains approval in Japan for a bechma as a third-line therapy for relapsed or refractory multiple myeloma, demonstrating its effectiveness in addressing unmet needs of multiple myeloma patients.
- Real-world evidence from the French Descartes registry suggests the potential of axocaptogene silolucile as an alternative treatment option for relapsed large B cell lymphoma patients, providing valuable insights into the use of CARTA cell therapies for patients who do not respond to first-line treatment or experience early relapse.
Deep dives
Bristol Myers Squibb receives approval in Japan for bechma in multiple myeloma treatment
Bristol Myers Squibb has obtained manufacturing and marketing approval in Japan for a bechma, Ida Cabbed Jean Vichlucil, as a third-line therapy for relapsed or refractory multiple myeloma. The approval is based on data from the Phase 3 CAR MMA-3 study, showing that a bechma demonstrated a 51% lower risk of disease progression or death compared to the standard regimen. The overall response rate was 71.3% in the a bechma arm, highlighting its effectiveness in addressing the unmet needs of multiple myeloma patients.
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