Health Check Behind the Huntington’s disease breakthrough
Dec 17, 2025
James Gallagher, a renowned BBC health correspondent, discusses the revolutionary gene therapy that may slow Huntington’s disease by 75%. He also reveals a case of a Danish donor whose sperm linked to a cancer gene has led to nearly 200 children. Mary Roach, popular science author, dives into the emotional dilemma surrounding amputation versus prosthetics and the advances in limb technology. Mohsen Rajabi sheds light on how teachers in Iran are crucial in providing mental health support for refugee children facing numerous challenges.
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First Effective Huntington’s Treatment
- A gene therapy trial transformed patients' brain cells into drug factories to reduce Huntington's toxic protein.
- Early data showed a 75% slowing of disease progression, turning one year of decline into four.
Expect Limited Access Initially
- The therapy requires delicate, lengthy brain surgery done under MRI guidance and is currently only in trials.
- Expect high costs and limited availability until regulatory approval and broader access are achieved.
Man Shot His Foot To Get A Prosthetic
- Mary Roach recounted a man with foot drop who shot his own foot to get a prosthetic and improved mobility.
- He preferred amputation and a prosthetic after surgeons refused elective removal despite functional limits.