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Astral Codex Ten Podcast

It's Fair To Describe Schizophrenia As Probably Mostly Genetic

Feb 9, 2024
Schizophrenia researcher E. Fuller Torrey and philosopher Awais Aftab discuss the genetic origins of schizophrenia. They question whether schizophrenia should be categorized as 'mostly genetic' and explore biases in twin studies and the interpretation of heritability numbers. They also explore the role of genetic and environmental factors in schizophrenia and debunk the misconception that genetic causes are less desirable. The podcast concludes by discussing different perspectives on classifying schizophrenia as an autoimmune, viral, or genetic disease.
21:31

Podcast summary created with Snipd AI

Quick takeaways

  • Schizophrenia should not be solely labeled as a genetic disease, even if studies show it to be 80% heritable.
  • Acknowledging the primarily genetic nature of schizophrenia can be a meaningful approach amidst its complex and multifactorial causes.

Deep dives

Schizophrenia is primarily genetic

The podcast discusses the arguments surrounding the heritability and genetic factors of schizophrenia. It explores the views of E. Fuller Tory, a famous schizophrenia researcher, who questions the dominant narrative that schizophrenia is mainly genetic. However, the podcast presents a counterargument by Oaius Aftab, who suggests that even if the studies show schizophrenia to be 80% heritable, it should not be solely labeled as a genetic disease. Nevertheless, the podcast asserts that given the various possible causes of schizophrenia and the prevalence of genetic factors, it is reasonable to consider schizophrenia as primarily genetic.

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