Psychiatry & Psychotherapy Podcast Valproic Acid: History, Mechanism, Treatment in Bipolar, Schizophrenia, Aggression and Side Effects with Dr. Cummings
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Jan 16, 2020 
Exploring the history and uses of Valproic Acid in treating conditions like bipolar disorder, schizophrenia, aggression, and dementia. Discussing its efficacy and side effects, including neutropenia, hepatotoxicity, and contraindications. Highlighting the importance of monitoring levels and managing potential side effects like hirsutism and alopecia.
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Valproic Acid Discovery and History
- Valproic acid was originally an inert solvent discovered to have anti-epileptic effects in 1962.
- It progressed from an anti-epileptic to a mood stabilizer used in bipolar disorder by the 1980s thanks to research by Dr. Robert Post.
Mechanism of Action Explained
- Valproic acid stabilizes the limbic system by blocking sodium channels and increasing GABA.
- It modulates neuronal excitability and helps the brain's natural chemicals maintain emotional balance.
Valproic Acid in Bipolar Disorder
- Valproic acid is as effective as lithium for acute mania in bipolar disorder but less effective for bipolar depression.
- It also provides longer prophylaxis between mood episodes than antipsychotics like olanzapine.