Psychiatry & Psychotherapy Podcast
Valproic Acid: History, Mechanism, Treatment in Bipolar, Schizophrenia, Aggression and Side Effects with Dr. Cummings
Jan 16, 2020
Exploring the history and uses of Valproic Acid in treating conditions like bipolar disorder, schizophrenia, aggression, and dementia. Discussing its efficacy and side effects, including neutropenia, hepatotoxicity, and contraindications. Highlighting the importance of monitoring levels and managing potential side effects like hirsutism and alopecia.
59:53
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Quick takeaways
- Valproic acid was initially discovered for epilepsy, later approved for stabilizing mood in bipolar disorder.
- Valproic acid's efficacy in treating aggression, impulsivity, and agitation showcases its versatility in various psychiatric conditions.
Deep dives
History and Development of Valproic Acid
Valproic acid, derived from valeric acid, was initially intended as an inactive solvent for medical research. In 1882, research unexpectedly revealed its anti-epileptic properties, leading to its approval in 1972. Dr. Robert Post's work in 1982 linked it to stabilizing mood in bipolar illness.
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