Masters in Business

Targeting Sickle Cell Disease (Sponsored Content)

May 18, 2025
David Altschuler, the Chief Scientific Officer at Vertex, dives into the pressing issue of sickle cell disease affecting 100,000 Americans. He discusses the company’s strategic focus on targeting this disease and the extensive R&D efforts behind it. The conversation touches on the social implications of sickle cell, particularly the challenges faced by African-American patients in accessing effective treatment. Insights on innovative therapies and the emotional toll on patients highlight the importance of compassionate care and the hope for improved patient outcomes.
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ANECDOTE

Terri's Pain and Stigma

  • Terri Booker described sickle cell pain as if someone twists your body in opposite directions.
  • She faced severe pain and was mistaken for a drug addict in emergency rooms, illustrating societal challenges.
INSIGHT

How Sickle Cell Causes Pain

  • Sickle cell disease causes red blood cells to become crescent-shaped, blocking oxygen flow.
  • This blockage causes severe pain due to lack of oxygen reaching tissues.
INSIGHT

Racism Impacts Sickle Cell Care

  • Racism and systemic inequities deeply impact sickle cell disease care for African Americans.
  • Access and quality of care are lower for this group, compounding health challenges.
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