The Curbsiders Internal Medicine Podcast

#329 Curing Hepatitis C: A Primary Care Primer

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Apr 18, 2022
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ADVICE

Universal Hepatitis C Screening

  • Screen all adults at least once for Hepatitis C using a universal approach instead of relying on risk factors.
  • High-risk groups like injection drug users and men who have sex with men need annual screening to catch ongoing infections early.
INSIGHT

Positive Antibody ≠ Active Infection

  • A positive hepatitis C antibody means exposure but not necessarily current infection.
  • Without detectable virus, the infection may have cleared spontaneously, so no treatment is needed for those cases.
ADVICE

Simplified Hepatitis C Workup

  • Use simplified workup including CBC, CMP, HIV testing, and hepatitis B serologies before Hepatitis C treatment.
  • Use fibrosis assessment tools like FIB-4, APRI, or elastography to stage liver disease and guide management.
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