Science Fictions Paid-only Episode 9: Viagra
Jun 25, 2024
Exploring the potential link between Viagra and Alzheimer's, the accidental discovery of Viagra for angina, the impact of protein kinases on blood vessels and erections, and a professor's unconventional presentation involving genitalia at a conference.
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Viagra And Alzheimer’s Questioned
- Recent studies have claimed sildenafil might prevent or slow Alzheimer's via vascular mechanisms.
- Tom and Stuart question whether this effect is plausible or overstated.
How Viagra Works Biochemically
- Viagra (sildenafil) works by inhibiting PDE5, raising cGMP and activating protein kinase G to relax smooth muscle.
- This vasodilation increases blood flow, explaining effects in angina and erections.