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The Studies Show
Paid-only Episode 9: Viagra
Jun 25, 2024
Exploring the potential link between Viagra and Alzheimer's, the accidental discovery of Viagra for angina, the impact of protein kinases on blood vessels and erections, and a professor's unconventional presentation involving genitalia at a conference.
10:32
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Quick takeaways
- Viagra's vascular mechanism may slow dementia effects by increasing blood flow.
- Early exploration with vasodilators, like Papavarin, sparked discussion on achieving erections.
Deep dives
The Science of Viagra and Its Mechanism of Action
Viagra, also known as sildenafil citrate, initially developed for angina, dilates blood vessels by inhibiting the enzyme PDE5. This inhibition increases the presence of CGMP, activating protein kinase G that relaxes smooth muscles, allowing blood flow. This mechanism proves useful for conditions like angina and also aids in achieving erections.
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