This podcast explores the potential of light therapy, specifically trans-cranial laser therapy, for treating Major Depressive Disorder (MDD). It discusses the challenges with traditional treatments and introduces the concept of photobiomodulation as a promising therapy technique with minimal side effects. The podcast also highlights the importance of optimizing dosing, targeting specific brain regions, and using the right brightness and color of light for optimal results. Additionally, it explores the therapeutic potential of infrared light and laser therapy on brain tissue, discussing their use in treating depression, addiction, and anxiety.
Trans-cranial laser therapy using specific wavelengths of near infrared light can be a safe and effective treatment option for major depressive disorder, producing minimal to no adverse effects.
Personalizing light therapy treatments based on age is crucial for achieving higher success rates and tolerability in treating major depressive disorder.
Deep dives
Potential of Non-Invasive Light Therapy for Major Depressive Disorder
This podcast episode explores the potential of non-invasive light therapy for treating major depressive disorder. Laser therapy, which uses safe light to stimulate positive changes in tissues, has traditionally been cleared only for painful conditions in the United States. However, recent research suggests that light therapy could be effective in treating non-painful conditions like major depressive disorder, addiction, and cognitive decline. By delivering specific wavelengths of near infrared light transcranially, light can penetrate the skull and target brain regions associated with emotion regulation, such as the ventromedial prefrontal cortex and dorsolateral prefrontal cortex. Studies have shown that light therapy can be a safe and effective treatment option for major depressive disorder, producing minimal to no adverse effects.
The Importance of Personalizing Light Therapy for Different Age Groups
This podcast episode highlights the need to personalize light therapy treatments for different age groups when addressing major depressive disorder. A study published in Neuro Photonics focused on simulating dosimetry and determining the optimal light dose for treating major depressive disorder across different age ranges. The simulation showed that light penetration to the brain decreases with age, with younger individuals experiencing quicker and better light penetration. However, even older adults with thicker skull tissues can benefit from light therapy in less than two minutes with the right light intensity. It is crucial to use the appropriate light strength and wavelength, with 810 nanometer wavelengths delivering the highest energy deposition to the brain. Personalization of light therapy treatments based on age is key to achieving higher success rates and tolerability.
Advancements and Hope for Light Therapy Treatment of Depression
This podcast episode discusses the advancements and potential for using light therapy to treat major depressive disorder. Major depressive disorder affects a significant portion of the US population, and current treatment options like antidepressant medications and psychotherapy have their limitations. Photobiomodulation, a near-infrared light-based therapy technique, has shown therapeutic effectiveness for various neuropsychiatric disorders, including major depressive disorder. Studies on both animals and humans have demonstrated the minimal or no adverse effects of light therapy while producing positive therapeutic effects. The ability to deliver safe amounts of light to the brain has become a focus of research, and recent advancements in simulating dosimetry and understanding light behavior through tissues like the skull have shown promising results. Although this treatment approach is still in the theoretical stage and not FDA-cleared, it presents a potential safe and effective alternative to current treatment methods for major depressive disorder.
Major Depressive Disorder is typically treated by anti-depressants and with psychotherapy, but there are challenges with these treatments including relapse and side-effects. The study reviewed in this podcast looks at trans-cranial laser therapy, from childhood through elderliness, by simulating how dosage and wavelengths affect trans-cranial photobiomodulation, for treatment of various neuropsychiatric disorders such as MDD, addiction, anxiety, and more.