Episode 69:DUPLEX Sparsentan, it’s no Acthar Gel

The Filtrate:

Joel Topf

Swapnil Hiremath

Priya Yenebere

Nayan Arora

With Special Guest:

Brendon Neuen Super smart guy and clinical trialist

Michelle Rheault Lead author of DUPLEX and friend of the pod

Show Notes

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis

NephJC Summary | PubMed | NEJM

KDIGO FSGS Guidelines 2021 (PDF)

Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications, A Scoping Review (JAMA Internal Medicine)

DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS (PubMed)

Vlado Perkovic, mentor and sponsor extradenoire (UNSW Sydney)

Shimer Its a floor wax and a desert topping (TikTok)

SONAR: Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease: a double-blind, randomised, placebo-controlled trial. (NephJC)

Travere Therapeutics Announces FDA Accelerated Approval of FILSPARIᵀᴹ (sparsentan), the First and Only Non-immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy (Travere press release)

GFR Slope: Chronic vs Total slope: A meta-analysis of GFR slope as a surrogate endpoint for kidney failure (Nature Medicine)

There are dozens of us! Dozens! (Know your Meme)

Brendon’s Neuen’s tweet about total versus chronic slope (X | Twitter)

Julie R. Ingelfinger, deputy editor for the New England Journal of Medicine (Wikipedia)

You know nothing, John Snow (YouTube shorts)

Tubular Secretions

Swapnil Foundation season two on Apple TV Wheel of Time season two Amazon Prime

Brendon Andor

Priya Poverty, by America Mattew Desmond

Nayan The Armor of Light: A Novel by Ken Follett

Michelle Lessons in Chemistry: A Novel by Bonnie Garmus