Parkinson’s disease has long been defined by the death of neurons in the brain. Yet, decades before tremors appear, the first signs emerge quietly in the gut. Recent evidence reveals a puzzling disappearance: microbial pathways that once produced two well-known compounds fall silent. Their absence strips away protective metabolites, erodes the intestinal barrier, and leaves neurons exposed to toxins that ignite α-synuclein fibrils. Could the vanishing of two simple vitamins be an overlooked trigger, and a potential target, in the unfolding mystery of Parkinson’s disease?
00:00 Introduction to Parkinson's Disease
00:35 Early Signs and Gut Connection
01:19 The Braak Hypothesis and Vagus Nerve
02:08 Gut Microbiome and Vitamin Pathways
03:10 Global Meta-Analysis and Key Findings
04:37 Impact of Vitamin Deficiencies
08:57 Potential for Vitamin Supplementation
11:20 Conclusion and Future Implications
PMID: 37314861