Orakl Oncology combines data and biology to bring new drugs to cancer patients
Dec 4, 2024
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The podcast dives into the alarming rise of cancer among younger adults and the staggering failure rates of new drug compounds in clinical trials. Fanny Jaulin discusses the need for innovative trial designs to improve outcomes. It highlights how a startup is leveraging AI to revolutionize drug discovery by tailoring treatments to individual patient profiles, particularly for colorectal and pancreatic cancers. Their recent funding successes signal a promising advance in the realm of precision medicine.
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Quick takeaways
Fanny Jolin emphasizes that redesigning clinical trials is crucial for improving drug development success rates amidst rising cancer cases.
Oracle Oncology leverages artificial intelligence to innovate drug discovery by integrating biological insights and data with advanced organoid testing methods.
Deep dives
Challenges in Cancer Drug Development
Cancer incidence is rising, particularly among younger adults, and most new drug compounds fail to advance through clinical trials. French entrepreneur Fanny Jolin highlights that the underlying problem often lies in the design of these clinical trials. She emphasizes that a drug's failure in trials does not necessarily indicate its ineffectiveness, pointing to the need for smarter trial methodologies. This situation underlines the importance of innovating within the clinical trial process to improve outcomes for cancer treatments.
AI-Driven Solutions for Trial Effectiveness
Oracle Oncology, founded as a spinoff from the Gustave Roussy Institute of Oncology, utilizes artificial intelligence to address the complexities of drug discovery. By combining data and biological insights, Oracle distinguishes itself in a crowded field where many companies focus solely on one aspect. The startup's approach includes creating organoids, which are simplified miniature versions of organs used for testing drug responses. With plans to launch two products—O-Predict for forecasting patient responses and O-Validate for drug validation—Oracle aims to enhance precision medicine and expedite the drug development process.
Cancer incidence is on the rise, particularly among younger adults, but most new drug compounds fail to progress through clinical trials. According to French entrepreneur Fanny Jaulin (on the right in the picture above), the problem lies with clinical trial design.