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Cell & Gene: The Podcast
Live from ARM's Meeting on the Mesa with Kiji Therapeutics' Dr. Miguel Forte
Oct 24, 2024
Miguel Forte, CEO of Kiji Therapeutics and President of ISCT, shares his insights on iPSC-MSC therapy for inflammatory diseases. He discusses Kiji's innovative approach to tackling conditions like graft-versus-host disease, inflammatory bowel disease, and psoriasis through advanced clinical trials. The conversation highlights the significance of strategic funding and global collaboration in biotechnology. Forte also reflects on the opportunities presented at ARM's meeting and the importance of networking for future technological advancements.
25:26
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Quick takeaways
- Kiji Therapeutics aims to revolutionize MSC therapy for inflammatory diseases by utilizing iPSC technology to ensure consistency and cost-effectiveness.
- The company is set to start a pivotal clinical trial for GVHD while pursuing collaborations to enhance development and accessibility of cell therapies.
Deep dives
Significance of Kiji Therapeutics
Kiji Therapeutics focuses on addressing the unmet medical needs associated with inflammatory diseases through the use of genetically engineered mesenchymal stromal cells (MSCs). The company aims to professionalize MSC therapy by utilizing induced pluripotent stem cells (iPSCs) to ensure consistency, scalability, and cost-effectiveness in manufacturing. By targeting inflammation through advanced engineering techniques, Kiji aims to produce therapeutic products that effectively modulate the immune system, specifically by secreting high levels of interleukin-10 (IL-10) at sites of inflammation. This strategic approach seeks to enhance the efficacy of MSC therapies beyond current offerings, showing promise in conditions like graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD).
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