VEXAS: Understanding the Newly Discovered Inflammatory Disorder

VEXAS is a rare inflammatory disorder primarily affecting elderly patients due to acquired changes in genetic codes that lead to disease pathogenesis. The name VEXAS stands for vacuoles, E for E1 ubiquitin enzyme, X for X-linked gene, A for auto-inflammatory features, and S for somatic mutations. The disorder presents with nonspecific inflammatory manifestations like fever, weight loss, and malaise, along with hematological issues like anemia and thrombotic events, often resembling myelodysplastic syndrome.