Neuroscientist Karl Friston discusses the meaning of life and how death shapes our perception. He explores mortal computation and provides real-world examples. The podcast also covers topics such as adaptive resonance theory, synaptopathy, Bayesian brains, mental health, and diverse intelligence field. Friston also mentions influential figures like Andy Clark, Mark Solms, Gerald Edelman, and Anil Seth.
Understanding and treating synaptopathies is important in healthcare as it directly impacts sensory processing, attentional gain, and sensory attenuation processes.
Collaboration and the integration of diverse perspectives from various disciplines are essential in advancing the field of neuroscience, psychology, and philosophy.
Deep dives
Synaptopathy and its Relevance to the Bayesian Brain and Healthcare
Synaptopathy refers to a pathology of synapses, the microscopic connections between brain cells that enable communication. It encompasses various conditions where synaptic connectivity is disturbed, leading to neurological or psychiatric diseases. Synaptic connections play a crucial role in the Bayesian brain and predictive processing, as they determine the connection weights in neuronal networks. Dysfunction or modulation of synapses can result in a breakdown of modulatory effects, affecting how prediction errors are reported and updating beliefs. Synaptopathies can disrupt precise modulation of synapses, leading to false inferences, such as hallucinations or neglect syndromes. Understanding and treating synaptopathies is important in healthcare, as it directly impacts sensory processing, attentional gain, and sensory attenuation processes.
The Significance of Sensory Attenuation and Sonatopathy in Understanding Psychiatric Disorders
Sensory attenuation refers to the brain's ability to filter out or suppress certain sensory signals. Sonatopathy, a failure of sensory attenuation, can lead to a range of psychiatric disorders. For example, in Parkinson's disease, the inability to ignore the fact that one is not moving due to precise top-down predictions overrides the intention to move. In severe autism, a failure to attenuate or ignore certain sensory signals, such as interception signals or signals from the gut, can lead to heightened attention and the need to find explanations for those signals, potentially resulting in somatization. Understanding sensory attenuation and sonatopathy is crucial in developing personalized and specialized pharmacotherapy and psychotherapy treatments for psychiatric disorders.
The Role of Precision and Felt Uncertainty in Consciousness
Precision, also known as felt uncertainty, plays a key role in consciousness. Precision control involves modulating synaptic connections to balance beliefs and prediction errors in the brain. Felt uncertainty refers to the subjective feeling associated with the level of precision in the brain's informational processing. The ability to modulate synaptic strengths and dissolve phenomenal transparencies enables the perception of objective, subjective, and even non-dual experiences. The insights gained from studying precision and felt uncertainty can inform fields like psychotherapy, helping patients understand the source and nature of their experiences, and empowering them with a sense of control and an understanding of the mechanics behind their sensory and perceptual processes.
The Avengers of Mind: Collaboration and Diverse Perspectives
Collaboration and the integration of diverse perspectives from various disciplines are essential in advancing the field of neuroscience, psychology, and philosophy. The convergence of ideas among leading researchers like Mark Somes, Chris Fields, Richard Watson, Jerry Edelman, and others is pushing the boundaries of our understanding. By dissolving the traditional boundaries between biology, physics, psychology, and philosophy, these thinkers are uncovering the shared underlying principles of the mind. Their discussions, debates, and collaborations create a rich tapestry of ideas that contribute to the advancement of our knowledge and provide new insights into consciousness, cognition, and mental health.
Professor Karl Friston is one of the most highly cited living neuroscientists in history. He is Professor of Neuroscience at King's College London and holds Honorary Doctorates from the University of Zurich, University of York and Radboud University. He is the world expert on brain imaging, neuroscience, and theoretical neurobiology, and pioneers the Free-Energy Principle for action and perception, with well-over 300,000 citations. Friston was elected a Fellow of the Academy of Medical Sciences (1999). In 2000 he was President of the international Organization of Human Brain Mapping. He was elected a Fellow of the Royal Society in 2006. He became a Fellow of the Royal Society of Biology in 2012 and was elected as a member of EMBO (excellence in the life sciences) in 2014 and the Academia Europaea in (2015).
TIMESTAMPS:
(0:00) - Introduction
(5:19) - The Meaning of Life
(9:18) - How Does Death Shape Life? Mortal Computation
(23:22) - Real World Examples of Mortal Computers (Micro to Cosmic)
(36:28) - Stephen Grossberg (Adaptive Resonance Theory)
(52:01) - Synaptopathy, Bayesian Brains, & Mental Health
(1:12:48) - Psychiatric Implications
(1:25:01) - Andy Clark (5E Theory)
(1:30:43) - Mark Solms (Felt Uncertainty Theory)
(1:39:10) - Michael Levin & Chris Fields & Richard Watson (Diverse Intelligence Field)
(1:44:08) - Gerald Edelman
(1:47:03) - Anil Seth (Awesome Story)
(1:50:14) - Book & Author Recommendations
(1:54:55) - Conclusion
EPISODE LINKS:
- Karl's Round 1: https://youtu.be/Kb5X8xOWgpc
- Karl's Website: https://www.fil.ion.ucl.ac.uk/~karl/
- Karl's Books: https://tinyurl.com/2s4e9rsk
- Karl's Publications: https://tinyurl.com/y3jw534u
- Karl's Wiki: https://en.wikipedia.org/wiki/Karl_J._Friston
CONNECT:
- Website: https://tevinnaidu.com/
- Podcast: https://podcasters.spotify.com/pod/show/drtevinnaidu
- Twitter: https://twitter.com/drtevinnaidu/
- Facebook: https://www.facebook.com/drtevinnaidu
- Instagram: https://www.instagram.com/drtevinnaidu/
- LinkedIn: https://www.linkedin.com/in/drtevinnaidu/
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Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.
#KarlFriston #Life #Death #FreeEnergyPrinciple
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