Freely Filtered 019: CRIC on NSAIDs v Opioids

The Filtrate:

Joel Topf

Swapnil Hiremath

Matt Sparks

And special guests:

Joshua Waitzman, third year nephrology fellow at Beth Israel

Harold “Harv” Feldman. Editor in Chief at AJKD and national study chair of CRIC and principal investigator of the Scientific and Data Coordinating Center of the CRIC Study. https://www.dbei.med.upenn.edu/bio/harold-i-feldman-md-msce

Show Notes:

CRIC: Chronic Renal Insufficiency Cohort http://www.cristudy.org/

NSAID Studies at NephJC:

Precision: http://www.nephjc.com/news/2017/1/20/hwgrko70d3z88djtjcmzvwpzlirm6c?rq=precision

Army of NSAIDs: http://www.nephjc.com/news/nsaids and the podcast (from before the name Freely Filtered, http://www.nephjc.com/freelyfiltered/2019/3/24/nephjc-drive-time-001-an-army-of-nsaids)

And this week’s study: CRIC: http://www.nephjc.com/news/nsaids-vs-opioids

Methods at 16:55

Matt had to get a mouse study 🐁 in, so here it is: Renal Abnormalities And An Altered Inflammatory Response In Mice Lacking Cyclooxygenase Ii https://www.nature.com/articles/378406a0

The Beth Israel Flex, “The first time I read the paper…”

Results at 32:46

Discussion 48:13

Josh King on opioids being nephrotoxic: https://twitter.com/nephrotox/status/1260400636253921281?s=20

This Week in Covid

The fight over round spikey things.

German autopsy study showing SARS-CoV2 in the kidney: https://www.nejm.org/doi/full/10.1056/NEJMc2011400

Kidney International walking back some previous declarations of what they are seeing on EM: https://twitter.com/Kidney_Int/status/1263641195416150018?s=20

MedRxIV on AKI with COVID-19 at Mount Sinai Medical Center: https://www.medrxiv.org/content/10.1101/2020.05.04.20090944v1

Juan Carlos discussing etiologies of AKI in COVID-19 outbreak in New Orleans.

https://kidney360.asnjournals.org/content/early/2020/05/13/KID.0002652020

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext

Friend of the Podcast, Kenar Jhaveri and his data on COVID19 and AKI in Kidney International. https://www.kidney-international.org/article/S0085-2538(20)30532-9/fulltext