The Jordan Harbinger Show 1241: Ketamine | Skeptical Sunday
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Nov 16, 2025 
Nick Pell, a writer and researcher, shares his insights on ketamine therapy, exploring its rise as a treatment for mental health issues like PTSD and depression. He discusses his personal experience with the therapy, emphasizing the importance of medical supervision. The conversation highlights the risks of recreational use, such as bladder damage, and the potential for dependency. Pell warns against the proliferation of telehealth clinics lacking proper vetting. He advises starting with a therapist for safe and effective treatment.
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Personal Ketamine Treatment Story
- Nick Pell underwent multiple ketamine IV sessions over about a year and a half for complex PTSD from childhood trauma.
- He reports major improvements in sleep and emotional volatility and stopped because he no longer needed it.
Clinical Setting Versus Recreational Use
- During sessions Nick lay in a chair, had an IV, and needed a medical attendant to monitor vitals and occasionally give meds.
- He experienced extreme dissociation and needed someone to hold his feet because he couldn't feel his body.
Host's Single Ketamine Session
- Jordan Harbinger shared his single supervised ketamine experience and found the trip disorienting and unpleasant.
- He concluded it's medicine, not a recreational activity, and wouldn't do it again without medical reason.