The Difference Between Pure Psilocybin and Full Spectrum Mushrooms with Lerer Bernard and Orr Shahar
May 22, 2024
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Researchers Lerer Bernard and Orr Shahar discuss the clinical difference between pure psilocybin and full spectrum mushrooms, exploring the entourage effect of compounds. They touch on therapeutic benefits, interactions between compounds, and the use of psychedelic mushrooms in treating psychiatric disorders.
The debate between pure psilocybin and full spectrum mushrooms with entourage effects sheds light on their clinical differences.
Exploration of how the combination of various compounds in psilocybin mushrooms influences brain function and synaptic plasticity.
The detailed extraction process used in the study highlights the importance of precise dosing and delivery methods.
Deep dives
Potential of Psychedelic Compounds in Treating Disorders
Research focuses on the treatment potential of psychedelic compounds, specifically psychedelic mushrooms containing psilocybin, in major psychiatric and neuropsychiatric disorders.
Importance of Examining Full Spectrum Mushroom Extracts
The study compared the effects of pure psilocybin and full spectrum mushroom extracts on mice, highlighting potential differences in the entourage effects of the extract components on synaptic proteins and metabolic pathways.
Understanding the Entourage Effect of Psilocybin Mushrooms
Exploration of the entourage effect in psilocybin mushrooms, discussing how the combination of various compounds in the mushroom, beyond psilocybin, influences brain function, synaptic plasticity, and offers potential therapeutic benefits.
Methodology in Extracting and Administering Compounds
Detailed extraction process and administration techniques used in the study, involving solvent extraction and spray drying to create a powder for injection, addressing the significance of precise dosing and delivery methods.
Future Research Directions and Ideal Circumstances
In ideal conditions with unlimited resources, researchers would delve deeper into understanding the mechanisms of psilocybin, DMT, and other psychedelic compounds, aiming to uncover their effects on neuroplasticity, neural pathways, and potential therapeutic applications.
Today we sit down with two researchers who just published the paper: "Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse brain" to discuss the clinical difference between pure chemically synthesized psilocybin versus full spectrum mushrooms with the entourage effect of different compounds. This has always been a debate in the psychedelic community and we're pleased to uncover the truth on todays episode.
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