

The Difference Between Pure Psilocybin and Full Spectrum Mushrooms with Lerer Bernard and Orr Shahar
May 22, 2024
Researchers Lerer Bernard and Orr Shahar discuss the clinical difference between pure psilocybin and full spectrum mushrooms, exploring the entourage effect of compounds. They touch on therapeutic benefits, interactions between compounds, and the use of psychedelic mushrooms in treating psychiatric disorders.
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Orr Shahar's First Psilocybin Trip
- Orr Shahar experienced his first psilocybin trip at 16, changing his worldview profoundly.
- His passion for mushrooms led to advanced research blending psychedelics and neuroscience.
Entourage Effect Explained
- The entourage effect means that compounds in mushrooms synergize beyond isolated psilocybin.
- Psilocybin mushrooms contain alkaloids and anti-inflammatory compounds that may enhance therapeutic outcomes.
Head Twitch Response as Measurement
- The head twitch response (HTR) in mice serves as a proxy for psychedelic experience.
- HTR intensity correlates with psychedelic dosage, helping study pharmacology.