The Internet Book of Critical Care Podcast IBCC Episode 16 - Immune Checkpoint Inhibitors
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Dec 19, 2018 Learn about the mechanism of immune checkpoint inhibitors and their toxicities. Explore bronchoscopy in immunosuppressed patients, management of side effects like fungal infections and colitis, and evaluation for nephritis.
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Checkpoint Inhibitor Mechanism
- Immune checkpoint inhibitors amplify T cell responses against tumors, similar to "cutting the brakes" of the immune system.
- These drugs share similar toxicity profiles, simplifying understanding across the class.
Checkpoint Inhibitor Use
- Checkpoint inhibitors treat various cancers, with expanding indications like small cell lung cancer.
- Historically, they've been used for melanoma, lung, renal, and hepatocellular cancers.
Increased Toxicity Risk
- Checkpoint inhibitor toxicities may increase due to broader application and combination therapies.
- Randomized controlled trials initially excluded many patient groups, and toxicities might have been underreported.