Media Claims Protein 'Damages Your Arteries' Here’s The Study Facts
Feb 28, 2024
auto_awesome
Debunking media claims of protein damaging arteries, the podcast delves into a study's flaws and implications. Discussing junk protein, canola oil, and the impact of plant vs. animal protein on heart disease. Exploring mTOR in immune cells, new mechanisms of heart disease, and the stimulation of mTOR by protein.
Study didn't assess artery health despite media claims.
Protein-rich meals may activate mTOR signaling linked to atherosclerosis development.
Deep dives
Study on Protein Consumption and Cardiovascular Risk
Research conducted on protein intake highlights a study examining the impact of protein consumption on atherosclerosis. The study focused on the effects of high versus low protein diets on mTOR signaling, a pathway associated with growth in the body. By analyzing 23 human subjects, the study revealed that protein-rich meals, particularly containing sugar-enriched and canola oil-infused proteins, might elevate processes linked to atherosclerosis. However, the study's animal model arm, involving mice genetically predisposed to cardiovascular issues, did not examine atherosclerosis markers directly in humans.
Role of Leucine in Protein Activation and Atherosclerosis
The study delved into the role of leucine, a branch chain amino acid, in activating the mTOR signaling pathway in macrophages, cells involved in the immune response. While high leucine levels can trigger mTOR activation in immune cells, the direct association between protein-induced mTOR in monocytes and atherosclerosis remains unclear. The study emphasized a threshold effect of leucine concentration on mTOR activation in macrophages, potentially contributing to a pathogenic environment related to atherogenesis.
Findings on Dietary Protein Intake and Atherosclerosis
The research indicated a dose-response relationship between dietary protein intake and mTOR activation, especially in monocytes and macrophages, both in humans and genetically modified mice. High dietary protein intake, particularly levels exceeding 25 grams per meal, was suggested to activate mTOR signaling in immune cells, potentially influencing atherosclerosis development. However, the study's use of processed and artificial protein sources raised questions about the generalizability and direct implications for human diets.
Sensational media coverage of a new study claims ‘protein damages your arteries' but upon deeper inspection, the study didn't even look at artery health.
0:00 Intro 0:07 Media Coverage 0:44 Actual study 1:34 Junk protein and canola oil 3:44 Graphical abstract 5:00 Immune cells and arterial plaque 6:04 Human arm of study 7:44 Mice prone to heart disease 8:50 Plant VS Animal protein 9:27 mTOR in immune cells 10:02 New mechanism of heart disease? 11:20 Human arm of study 12:13 Protein used in study 14:13 Protein stimulates mTOR 15:40 Study conclusions
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode