Can You Mimic Fasting—Without Actually Fasting?

Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health.

Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food.

Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation.

For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating.

What You’ll Learn:

• The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours)

• The four fasting metabolites that extend life by 96%

• How Mimio mimics fasting benefits—without giving up food

• The real reason over-fasting destroys your metabolism and hormones

• Why traditional longevity drugs (Metformin, Rapamycin) fall short

• Can you build muscle and burn fat at the same time? The science of mTOR & AMPK

• Why Big Pharma doesn’t want you to know about this breakthrough

*** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE ***

Sponsors:

Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Mimio Instagram: https://www.instagram.com/mimiohealth/

• Mimio Website: https://mimiohealth.com/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 – Intro

• 00:58 – Fasting & Longevity

• 01:88 – Optimal Fasting Length

• 03:39 – Alternate Day Fasting: Pros & Cons

• 05:50 – Key Fasting Compounds

• 07:34 – Spermidine & Longevity Molecules

• 11:41 – FDA Roadblocks on Natural Compounds

• 15:37 – AI, Big Data & Longevity Research

• 31:19 – Mimio’s Impact on Testosterone & Aging

• 35:16 – Longevity & Death Philosophy

• 36:48 – Biohacking Origins

• 37:03 – Metabolism & Cognitive Function

• 38:35 – Unexpected Effects of Fasting

• 40:43 – Fasting & Circadian Rhythms

• 43:09 – Mimio Science & Benefits

• 45:14 – Mimio in a Daily Routine

• 55:05 – Men vs. Women: Fasting Differences

• 01:02:23 – Future of Nutrition & Biohacking

• 01:07:21 – Conclusion & Discount Code

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Episode 75: I'll Be Your Villain (Diddy arrest, RHOC, RHODubai, RHOSLC)