Child Neurology Society's Brainstorm CNS Brainstorm Episode 26 "MOG Antibody Disease" with guest Dr. Grace Gombalay
Mar 23, 2025
Dr. Grace Gombalay, an Assistant Professor of Neurology and Pediatric Neuroimmunologist at Emory University, sheds light on the intriguing MOG Antibody Disease. They discuss its varied presentations, such as optic neuritis, and the diagnostic challenges posed by similarities with other conditions. The conversation delves into evaluation techniques, including MRI and spinal fluid analysis, as well as initial treatment strategies. Gombalay emphasizes the importance of understanding MOGAD's distinctions from other demyelinating disorders, alongside insights from emerging research and clinical trials.
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MOGAD Is A Distinct Spectrum Disorder
- MOG antibody disease (MOGAD) is a spectrum of CNS inflammatory disorders defined by a MOG antibody and compatible phenotype.
- It includes demyelination and encephalitis and was testable in the U.S. starting in 2017.
Presentation Varies With Age And Phenotype
- MOGAD presentations vary by phenotype and age, including optic neuritis, ADEM, transverse myelitis, and NMOSD-like syndromes.
- Younger children tend toward ADEM while adults more often show NMOSD phenotypes.
MOGAD Mimics Many CNS Conditions
- MOGAD can mimic meningitis, autoimmune encephalitis, CNS vasculitis, and even tumor-like lesions on biopsy.
- This phenotypic diversity means clinicians must consider MOG testing in many atypical CNS presentations.