Hi everyone,

I’m delighted to have on molecular biologist and fellow freedom fighter on the podcast today. In this conversation, we discuss a new Nature paper that highlights the potential problems with the modified mRNA used in the COVID-19 vaccines. Dr. Rose explain the process of mRNA and protein translation, as well as the role of codon optimization. The conversation delves into the implications of N1-methyl pseudouridine and frame shifting, which can lead to the production of unintended proteins. We also discuss the unpredictability of dosing and the need for further research to understand the potential risks associated with the modified mRNA vaccines.

Chapters

00:00 Introduction and Background

07:05 Discussion on COVID Work

08:34 Introduction to the Nature Paper

09:01 mRNA and Protein Translation

13:25 Modified mRNA and Protein Production

29:24 N1-methyl Pseudouridine and Frame Shifting

36:05 Discussion on the Nature Paper

45:37 Implications and Unknowns

52:04 Predictability and Dosing

53:01 Codon Optimization and Slippery Sequences

54:56 Codon Optimization and Protein Production

55:54 Implications of Increasing GC Content

56:49 Ribosomal Pausing and Frame Shifting

59:08 Co-Translational Folding

01:00:06 The Potential of the mRNA Platform

01:01:31 The Complexity of the Human Body

01:03:17 Safety and Regulatory Considerations

01:05:40 Challenges of Coding Different Proteins

01:07:01 The Need for Regulatory Processes

01:09:21 Takeaways and Implications

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