Neurology Minute Eculizumab Use in Neuromyelitis Optica Spectrum Disorders
Nov 1, 2024
Discover the revolutionary use of eculizumab, a complement inhibitor, in treating Neuromyelitis Optica Spectrum Disorders. The conversation highlights its unique mechanism and discusses essential precautions, including vaccination and antibiotics, to ensure patient safety. Tune in to explore the potential side effects and the future of this innovative therapy.
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Protect Patients From Encapsulated Bacteria
- Vaccinate patients against encapsulated bacteria before starting eculizumab when possible.
- Alternatively, begin antibiotic prophylaxis and vaccinate soon after to reduce infection risk.
Complement Drives NMOSD Pathology
- AQP4-antibody positive NMOSD is driven by complement-mediated astrocyte and vascular damage.
- Blocking complement yields highly effective disease control in NMOSD patients.
Eculizumab Is Highly Effective
- Eculizumab and related complement inhibitors represent a very effective immunotherapy class for NMOSD.
- Their potency stems from directly blocking the complement cascade that mediates astrocyte injury.