JAMA Network JAMA Ophthalmology : Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy
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Oct 30, 2025 Noemi Lois, a Professor of Ophthalmology at Queen's University Belfast, dives into her groundbreaking study on retinal sensitivity and perfusion in diabetic retinopathy. She discusses how retinal sensitivity is mapped using advanced perimetry techniques. Lois highlights the importance of focusing on functional outcomes and the correlation between ischemic and perfused areas. Over time, sensitivity in non-perfused zones showed modest declines, while some perfused areas retained normal sensitivity, raising hope for early interventions.
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Point-To-Point Sensitivity Mapping
- The study mapped visual field–style retinal sensitivity points onto fluorescein angiography to enable point-to-point correlation.
- Testing covered macula, mid-periphery, and anterior retina across a 110° field for detailed spatial analysis.
Patients Value Function Over Appearance
- Patients prioritize retinal function over retinal appearance, guiding outcome selection for trials.
- The team found little prospective data on peripheral ischemia and function, motivating their longitudinal study.
Include Function As A Trial Outcome
- When designing trials for retinal ischemia, include functional outcomes, not just structural measures.
- Measure baseline natural history of function first to choose appropriate trial endpoints.