Beyond Heartburn: Probing the Association Between Proton Pump Inhibitor and Dementia

Sep 1, 2023

Explore the potential link between proton pump inhibitors (PPIs) and an increased risk of dementia. Discuss the impact of PPIs on stomach pH and the role of the gastrointestinal system in overall health. Examine the relationship between diet, food sensitivities, and reflux, and the use of PPIs. Discover the connection between memory problems, acid reflux, and PPIs in a patient's case. Learn about risk factors for acid reflux and the importance of collaboration with healthcare providers. Understand the significance of consulting GI specialists for gastrointestinal conditions and making informed medication decisions.

Ask episode

Chapters

Transcript

Episode notes

Introduction

00:00 • 3min

The Impact of Proton Pump Inhibitors on Stomach pH

03:21 • 9min

The Relationship Between Diet, Food Sensitivities, and Reflux, and the Role of Proton Pump Inhibitors

11:52 • 2min

The Impact of PPIs on Memory and Acid Reflux

13:28 • 23min

Identifying Risk Factors for Acid Reflux

36:46 • 2min

Understanding the Nuance of Proton Pump Inhibitor Use and Medication Choices

38:36 • 4min

In this episode In this illuminating episode, we dive deep into the world of proton pump inhibitors (PPIs), commonly prescribed medications for heartburn and acid reflux. While these drugs have brought relief to millions worldwide, recent studies have begun to uncover potential links between PPI use and an increased risk of dementia. We explore the mechanisms that might underlie this association, the clinical implications for patients, and the broader question of how seemingly unrelated conditions might be connected at a molecular level. Whether you're a healthcare professional, a patient on PPIs, or simply someone curious about the intricate web of human health, this episode promises to offer fresh insights into a hotly debated area of medicine.

References:

Main papers disucssed in this episode:

- Northuis, Carin, et al. "Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study." Neurology (2023).

https://n.neurology.org/content/early/2023/08/09/WNL.0000000000207747?utm_source=twitter&utm_medium=organic

- Gomm, Willy, et al. "Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis." JAMA neurology 73.4 (2016): 410-416.

https://jamanetwork.com/journals/jamaneurology/article-abstract/2487379

- Li, Min, et al. "Proton pump inhibitor use and risk of dementia: systematic review and meta-analysis." Medicine 98.7 (2019).

- Ortiz-Guerrero, Gloria, et al. "Proton pump inhibitors and dementia: physiopathological mechanisms and clinical consequences." Neural plasticity 2018 (2018).

- Wijarnpreecha, Karn, et al. "Proton pump inhibitors and risk of dementia." Annals of translational medicine 4.12 (2016).

- Haenisch, Britta, et al. "Risk of dementia in elderly patients with the use of proton pump inhibitors." European archives of psychiatry and clinical neuroscience 265 (2015): 419-428.

- Batchelor, Riley, et al. "Dementia, cognitive impairment and proton pump inhibitor therapy: a systematic review." Journal of gastroenterology and hepatology 32.8 (2017): 1426-1435.

- Gray, Shelly L., et al. "Proton pump inhibitor use and dementia risk: Prospective population‐based study." Journal of the American Geriatrics Society 66.2 (2018): 247-253.

- Ahn, Nayeon, et al. "Do proton pump inhibitors increase the risk of dementia? A systematic review, meta‐analysis and bias analysis." British Journal of Clinical Pharmacology 89.2 (2023): 602-616.

Join the NEURO Academy: NEUROacademy.com

Instagram: The Brain Docs @thebraindocs

Facebook: The Brain Docs

TikTok: @thebraindocs

Website: TheBrainDocs.com