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The Brain Health Revolution Podcast
Beyond Heartburn: Probing the Association Between Proton Pump Inhibitor and Dementia
Sep 1, 2023
Explore the potential link between proton pump inhibitors (PPIs) and an increased risk of dementia. Discuss the impact of PPIs on stomach pH and the role of the gastrointestinal system in overall health. Examine the relationship between diet, food sensitivities, and reflux, and the use of PPIs. Discover the connection between memory problems, acid reflux, and PPIs in a patient's case. Learn about risk factors for acid reflux and the importance of collaboration with healthcare providers. Understand the significance of consulting GI specialists for gastrointestinal conditions and making informed medication decisions.
42:47
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Quick takeaways
- Long-term use of proton pump inhibitors (PPIs) for acid reflux is associated with a 33% higher risk of developing dementia, potentially due to mechanisms like vitamin B12 deficiency and alteration of drug metabolism.
- Lifestyle modifications, including avoiding trigger foods and maintaining a healthy weight, can help manage acid reflux, reducing the need for long-term PPI use and potential associated risks.
Deep dives
Impact of Proton Pump Inhibitors on Dementia Risk
Proton pump inhibitors (PPIs), commonly used to treat acid reflux, have been linked to an increased risk of dementia. Studies have shown that long-term use of PPIs can result in a 33% higher risk of developing dementia. While the exact causal relationship is still being studied, several mechanisms have been proposed, including vitamin B12 deficiency, modulation of degradation of amyloid-beta proteins, alteration of drug metabolism, and potential changes in the gut microbiome. It's important to note that while this association exists, it doesn't mean that PPIs are the sole cause of dementia, as other factors such as lifestyle and comorbidities can also contribute. However, individuals should be aware of the potential risks associated with long-term PPI use and explore alternatives if appropriate.
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