In 2011, Loren O’Keeffe’s 24-year-old brother Daniel disappeared from their family home in Victoria, Australia. Loren says the search for her brother gave her purpose. In 2013, she founded the Missing Persons Advocacy Network (known as MPAN), now known as TheMissed Foundation. Loren offers insight into her personal experience with missingness and explains why it's important to reframe Missing Persons as a Public Health Issue.