82: Dr. Kristine Burke on Preventing Cognitive Decline with Functional Medicine and AI

In this episode of the MindHealth360 Show, Dr. Kristine Burke – triple board-certified precision medicine physician, educator and co-founder of TruNeura – joins me for a wide-ranging conversation on functional medicine, prevention and the future of brain health.

Drawing from her background as a family physician, sports doctor and functional medicine pioneer, Dr. Burke explains how chronic disease, cognitive decline and even conditions like Alzheimer’s can be prevented or reversed by addressing root causes such as inflammation, cardiovascular dysfunction, metabolic imbalance, toxins and hormone changes. She highlights her clinical work in mold-related illness and its profound effects on cognition and shares how her integrative systems-based approach empowers patients to reclaim both health and hope.

We discuss Dr. Burke’s excitement about TruNeura, the AI-driven platform she co-founded, designed to support both patients and practitioners in managing the overwhelming complexity of precision medicine. With AI-powered coaching and decision support, TruNeura helps scale prevention and treatment of cognitive decline worldwide.

This episode blends deep clinical insight with cutting-edge innovation, offering practical strategies to protect the brain and body, and a hopeful vision of how technology and root-cause medicine together may transform the future of mental health care.

In this episode, you’ll learn:

• How Dr. Burke’s journey from sports medicine to functional medicine reshaped her approach to chronic illness and prevention.

• Why root causes such as metabolic health, hormones, cardiovascular function, gut/oral microbiome, toxins and mold play a critical role in cognitive decline.

• The surprising links between mold exposure, biotoxins and brain health.

• How mindfulness, stress resilience, community and connection are essential pillars of brain health.

• The role of diet in prevention vs. therapy – from the Mediterranean diet to targeted ketogenic interventions.

• How TruNeura uses AI to empower patients, streamline clinical decision-making and scale precision medicine worldwide.

• Why prevention offers the greatest opportunity for preserving cognitive health and reducing the burden of neurodegenerative disease.