The podcast covers the latest innovation in neuroscience, including a differentiated approach to developing therapeutics for neurodegenerative diseases, the potential of digital biomarkers to improve drug development, and efforts to enhance technologies for neuroscientists.
Oligomerix utilizes a differentiated approach to develop cost-effective, orally administered tau protein inhibitors for neurodegenerative diseases.
Digital biomarkers offer objective, quantifiable measures for CNS disorders, but the lack of universally accepted biological markers in psychiatric and neurological diseases remains a challenge.
Deep dives
Taking a New Approach to Tackle Neurodegenerative Diseases
Oligomerics, a clinical stage biotechnology company, uses a differentiated approach to develop therapeutics for neurodegenerative diseases. They focus on tau protein inhibitors that can be administered orally and are cost-effective. Their lead candidate, Oligomerics' 07010, has shown promising results in reducing aggregated tau in animal models of neurodegeneration, leading to improved motor activity.
The Rise of Digital Biomarkers in Neuroscience Drug Development
Digital biomarkers are increasingly used in drug discovery for central nervous system (CNS) disorders. They offer objective, quantifiable measures obtained through electronic devices, improving accuracy and enabling real-time data collection. Digital biomarkers can play a crucial role in patient monitoring, disease diagnosis, and drug efficacy evaluation. However, the lack of universally accepted biological markers in psychiatric and neurological diseases remains a challenge.
Keeping Technology at the Forefront of Neuroscience Research
Inscopex, a neurotechnology company, focuses on understanding brain circuit activity to develop improved treatments for brain and nervous system disorders. Their miniature microscope technology, called miniscope, enables real-time visualization of brain circuits and correlations with behavior. By studying neural circuits at the mesoscale level, researchers gain insights into the functioning and dysfunction of the brain, paving the way for targeted interventions and more effective medicines.
In the first article, William Erhardt, President, Head of Development & Operations of biotech Oligomerix, tells Lu Rahman about the company’s differentiated approach to developing disease-modifying therapeutics for neurodegenerative diseases.
In the second article, Dr J Mark Treherne, Dr Jenny Barnett and Dr Paula Moran answer the question of whether an expansion in the use of effective digital biomarkers will help improve the productivity of drug development in neuroscience.
In the third article, David Gray, CSO of Inscopix talks to Lu Rahman about the company’s understanding of the neuroscience market and its quest to improve technologies for neuroscientists to enable multimodal research.