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Brain Science with Ginger Campbell, MD: Neuroscience for Everyone
BS 211 Molecular Biologist Seth Grant
Aug 25, 2023
Molecular biologist Seth Grant discusses the lifespan of synapse proteins and its implications for aging, memory, and diseases. The podcast explores the role of molecular biology in neuroscience, the challenges of choosing research projects, and the complexities of synapses in vertebrates and invertebrates, including octopuses.
01:10:15
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- Proteins in synapses have varying lifespans, with longer lifespans associated with resistance to aging.
- There is a wide range of synapse types and subtypes with different protein compositions, opening up possibilities for targeted therapies.
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Synaptic Protein Lifetime and Its Implications for Aging
The recent paper published in Neuron titled 'A Brain Atlas of Synapse Protein Lifetime Across the Mouse Lifespan' explores the duration that proteins stay in synapses and how it relates to aging. By studying the protein lifetime in mouse synapses, the researchers found that synapses with long protein lifetimes are more resistant to aging, while those with short protein lifetimes are more vulnerable. These findings shed light on the changes that occur in the brain during normal aging and provide a new perspective on age-related memory decline. Further research is needed to understand the molecular differences between these synapses and their implications for memory and neurodegenerative diseases.
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