Brain Science with Ginger Campbell, MD: Neuroscience for Everyone

BS 211 Molecular Biologist Seth Grant

6 snips

Aug 25, 2023

Molecular biologist Seth Grant discusses the lifespan of synapse proteins and its implications for aging, memory, and diseases. The podcast explores the role of molecular biology in neuroscience, the challenges of choosing research projects, and the complexities of synapses in vertebrates and invertebrates, including octopuses.

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Introduction

00:00 • 3min

The Integration of Molecular Biology in Neuroscience

03:22 • 28min

Modifying Genes to Study Synapses in the Brain

31:44 • 4min

Lifespan of Synapse Proteins: Implications for Memory and Behaviors

36:06 • 23min

Complexity of Synapses in Vertebrates, Invertebrates, and the Octopus

59:21 • 4min

The Challenges of Choosing Research Projects

01:03:07 • 6min

Announcements and Key Ideas

01:09:13 • 3min

This episode of Brain Science features the return of molecular biologist Seth Grant. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine.

Papers discussed in this episode:

Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. https://doi.org/10.1016/j.neuron.2022.09.009
Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. https://doi.org/10.1126/science.aba3163

Seth Grant has previously appeared on Brain Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176.

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