PRS Journal Club “Young Stromal Cell Effect on Fat Graft” with Chris Campbell, MD - Jun. 2025 Journal Club
Jun 18, 2025
Chris Campbell, MD, a leading expert in microsurgery and plastic surgery at the University of Virginia, joins young resident ambassadors to delve into groundbreaking research. They discuss how young adipose-derived stromal cells significantly enhance fat graft retention. The conversation explores the implications of age on graft success, innovative techniques using hydrogels, and the future of fat grafting methods. Insights into improving patient outcomes and evolving technology in breast reconstruction offer listeners a glimpse into the forefront of plastic surgery advancements.
AI Snips
Chapters
Transcript
Episode notes
Young Stromal Cells Boost Old Fat Grafts
- Supplementing aged fat with young adipose-derived stromal cells increased retention to about 65% in a murine model.
- The young stromal cells showed higher proliferation and lower senescence on histology.
Counsel Older Patients On Lower Retention
- Use study data to counsel older patients that age may reduce fat graft retention due to altered pre-adipocyte signaling.
- Expect comparatively lower retained volume in patients in their 70s and 80s.
Regulatory Hurdles Limit SVF Use
- Enzymatic digestion of fat to enrich stromal vascular fraction remains investigational under current regulations.
- That regulatory reality constrains translating cell-assisted lipotransfer into routine clinical care.