StarTalk Radio
Assembloids: Recreating the Brain with Sergiu Paşca
May 2, 2025
Sergiu Pașca, a Stanford neuroscientist and stem cell biologist, explores groundbreaking concepts in neuroscience. He discusses assembloids—self-organizing brain circuits that offer insights into brain function and conditions like autism. The conversation dives into the development of cultured brain cells and their unique 'brain clock.' Ethical considerations in psychiatric research and the potential for CRISPR technology are also examined. Pașca emphasizes the importance of these innovations in understanding mental health and advancing treatments.
01:05:24
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Quick takeaways
- Assembloids, self-organizing brain circuits, simulate complex interactions in the brain and aid in understanding neurological disorders.
- The manipulation of stem cells allows for the creation of models that represent individual genetic profiles, enhancing personalized medicine.
Deep dives
Understanding Assembloids
Assembloids are advanced models in neuroscience created by assembling organoids, which are clusters of cells cultured to mimic certain brain functions. Unlike organoids that represent parts of an organ, assembloids can work together to simulate more complex brain interactions. This innovation arises from the need to understand the biological mysteries of the human mind by utilizing self-organizing biological structures. The potential applications range from uncovering neurological disorders to paving the way for new treatments in the field of psychiatry.
