Nature Podcast Audio long read: How quickly are you ageing? What molecular ‘clocks’ can tell you about your health
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Mar 28, 2025 Delve into the fascinating world of molecular clocks and how they reveal your biological age versus chronological age. The podcast explores the evolution of molecular tests, highlighting both their health implications and commercialization concerns. Discover the balance between scientific excitement and public apprehension regarding these aging assessments. Learn about innovative methods such as brain scans and the popular engagement with DNA methylation, blending science with cultural trends.
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Kardashian's Epigenetic Test
- Kim Kardashian used a commercial epigenetic test revealing a younger biological age than her chronological age.
- This publicity concerned researchers like Terry Moffitt, who helped develop the test for medical use, not reality TV.
Biomarker Uncertainties
- Scientists are developing tests to measure aging's impact, using biomarkers like DNA methylation.
- While promising for therapies, results are often interpreted without acknowledging uncertainties, causing confusion and hype.
Epigenetic Clocks
- Steve Horvath developed an epigenetic clock using methylation sites to predict chronological age accurately.
- Later clocks aimed to predict time to death and health status, correlating with lifestyle factors.