Leaky gut isn’t just about digestion—it’s also messing with your brain. In this episode of Peptides and Longevity, Kiran Krishnan, a research microbiologist, breaks down the gut–brain connection and why a leaky gut can fuel inflammation, brain fog, and mood issues. He also reveals groundbreaking research on spore-based probiotics—how they repair the gut lining, calm inflammation, and may even help reprogram metabolism for better energy and body composition.

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A mass extinction is happening inside your gut—and it’s fueling everything from brain fog to autoimmunity. In this episode of Peptides and Longevity, Kiran Krishnan explains why the microbiome is not just trillions of organisms, but a vast genetic toolkit that powers most of our body’s chemistry. He warns that modern living is driving a ‘mass extinction’ of gut species, weakening immune training, fueling leaky gut, and setting the stage for allergies, autoimmunity, and chronic illness.

Krishnan then connects the dots to the brain, showing how toxins from a leaky gut trigger inflammation, brain fog, mood issues, and even neurodegeneration. He shares evidence on how spore-based probiotics restore gut diversity, strengthen keystone species, repair the gut barrier, and lower inflammatory markers—sometimes in as little as a month. Krishnan also highlights a pilot study where spores and prebiotics reduced visceral fat and improved insulin health without diet changes, pointing to true ‘metabolic reprogramming.’ He wraps up with a reality check on overhyped probiotics and testing, urging a smarter, science-based approach to gut health.

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Kiran Krishnan is a research microbiologist with over two decades of experience in the field of nutrition and supplements. Trained in molecular medicine and microbiology at the University of Iowa, he went on to hold leadership roles in global product development before becoming General Manager of Novozymes One Health America, Microbiome Labs. A sought-after speaker at medical and nutrition conferences, he is known for making complex science on the human microbiome practical and accessible. He is actively involved in more than a dozen human clinical trials, serves on multiple scientific advisory boards, and holds peer-reviewed publications and global patents in probiotic and microbiome research.