Freely Filtered 020: SGLT2i are diuretics, but not like any other diuretics

The Filtrate:

Joel Topf

Swapnil Hiremath

Samira Farouk

Matt Sparks

And special guests:

Sadiya Kahn a heart failure specialist at Northwestern University. @HeartDocSadiya

and

Paul Welling a professor of medicine and nephrology at Johns Hopkins. @PAWellingMD

Show Notes:

The Study: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.120.045691

Coverage at NephJC: http://www.nephjc.com/news/sglt2mechanism

Diuretics for heart failure NEJM Review article: https://www.nejm.org/doi/full/10.1056/nejmra1703100

Don’t say renal: https://www.kidney-international.org/article/S0085-2538(20)30233-7/fulltext?mobileUi=0

Sanjiv “We pronounce HFpEF huff-puff” Shah, MD https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16814 and https://asecho.org/wp-content/uploads/2016/02/Shah-HFpEF.pdf

Huff Puff is like fetch. It is not going to happen. https://www.youtube.com/watch?v=Pubd-spHN-0

Did he have buttons? https://ajkdblog.org/2019/06/17/muscle-relaxant-use-in-dialysis/

Rate My Room: https://twitter.com/ratemyskyperoom?lang=en

Review on Renal Glucosuria from CJASN: https://cjasn.asnjournals.org/content/5/1/133 and another from the National Organizations of Rare Disorders: https://rarediseases.org/rare-diseases/renal-glycosuria/

Mechanism of Impaired Natriuretic Response to Furosemide during Prolonged Therapy: https://pubmed.ncbi.nlm.nih.gov/2811065/

Two studies that showed drops in BNP with SGLT2i

DAPA HF: https://www.nejm.org/doi/full/10.1056/NEJMoa1911303

DEFINE HF showing nice reduction BNP with dapagliflozen: https://pubmed.ncbi.nlm.nih.gov/31524498/?dopt=Abstract

Copeptin, what is it? https://pubmed.ncbi.nlm.nih.gov/18291667/?dopt=Abstract

SIADH treatment with empagliflozen: https://jasn.asnjournals.org/content/31/3/615.abstract and it is JASN not CJASN. My bad.

EVEREST. Tolvaptan for heart failure: https://jamanetwork.com/journals/jama/fullarticle/206251

Remdesivir placebo controlled RCT: https://www.nejm.org/doi/full/10.1056/NEJMoa2007764

Joel’s Remdesivir study: https://www.nejm.org/doi/full/10.1056/NEJMoa2007016

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19: https://www.nejm.org/doi/full/10.1056/NEJMoa2015301

Swap showing a lot of skepticism to the Lancet HCQ data even before the retraction (which happened after this recording) https://www.the-scientist.com/news-opinion/lancet-retracts-surgispheres-study-on-hydroxychloroquine-67613

Baclofen is dangerous https://www.kidney-international.org/article/S0085-2538(20)30552-4/abstract