Are 49ers ready for prime time vs. Bills with odds stacked against them?

Matt Maiocco and Jennifer Lee Chan discuss the 49ers' mounting injuries entering their prime-time matchup with the Bills on NBC's "Sunday Night Football," including a previously undisclosed ankle fracture to star linebacker Fred Warner. Matt and Jennifer also analyze which three players on offense and defense have performed lower or been available significantly less compared to their standout 2023 seasons. Later, Matt and Greg Papa discuss if inclement weather will play a role in Buffalo, as well as keys to San Francisco making the Week 13 matchup competitive.

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(1:00) 49ers injury updates

(10:00) Comparing 2023 49ers to 2024 team, which mathematically is still in the playoff hunt

(13:00) Offensive, defensive players whose production fell significantly between last season and this season

(22 :00) How inclement weather in Buffalo could affect SNF game

(24:00) Which backup QB should play if Purdy sits out again?

(32:00) Keys to 49ers coming out competitive vs. Bills