Optimal Protein Podcast with Vanessa Spina Study Reveals NEW Hormone LEAP2 Behind How High Protein Diets Generate Ketones & Appetite Supression
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In today’s episode of The Optimal Protein Podcast, we uncover a groundbreaking discovery about LEAP2, a newly identified hormone that plays a key role in hunger regulation, ketone production, and appetite suppression.
We are breaking down a 2022 study published in Endocrinology titled b-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2 (PubMed link).
This research reveals how ketones specifically b-hydroxybutyrate (BHB) interact with LEAP2 and the hunger hormone ghrelin, explaining why high-protein, low-carb, and ketogenic diets naturally reduce appetite and support fat loss.
If you’ve ever wondered why a high-protein diet helps you stay full longer while promoting fat-burning, this episode explains the new science behind it!
Key Takeaways
-What is LEAP2? The newly discovered hormone that regulates hunger and ketone metabolism.
-How high-protein diets generate ketones, even without high fat intake.
-The role of BHB in appetite suppression.
-How LEAP2 interacts with ghrelin, the hunger hormone.
-Why hunger may temporarily increase when starting ketosis but decrease over time.
-How this research explains the long-term appetite-suppressing effects of ketogenic and high-protein diets.
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Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.