ID:IOTS - Infectious Disease Insight Of Two Specialists 121. Moulds: Mucorales
Oct 6, 2025
Dr. Dora Corzo-Leon, an infectious diseases specialist with a PhD in molecular mycology, joins Callum and Alyssa to delve into the world of Mucorales and mucormycosis. They discuss the confusing taxonomy and diverse species that pose serious health risks, especially in high-risk patients. The conversation highlights the critical role of surgery and antifungal treatments, alongside the rise of COVID-associated mucormycosis in India. With insights into diagnostics and the importance of prompt intervention, this episode is a deep dive into an often-overlooked threat in infectious disease.
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Mucorales Are Under-Recognized And Neglected
- Mucorales are a large, under-recognized group with >200 species and limited diagnostic tools.
- New antifungal pipelines largely ignore Mucorales, making them a neglected research priority.
Two Dominant Clinical Phenotypes
- Two clinical phenotypes dominate: diabetic patients with rhino-orbital-cerebral disease and neutropenic/hematology patients with pulmonary disease.
- Outbreaks occur after disasters and COVID-19 revealed additional at-risk populations.
Always Combine Surgery With Antifungals
- Do prioritise urgent surgical debridement alongside antifungals; surgery often determines outcome.
- Request surgical input early and treat medically and surgically at the same time.