Episode 21. Newly Diagnosed Mantle Cell Lymphoma

In this episode, we delve into the management of newly diagnosed mantle cell lymphoma with Dr. Martin Dreyling. Here the shownotes:

2:11 How to diagnose mantle cell lymphoma (MCL)?

6:51 Clinical manifestations of mantle cell lymphoma

7:52 How to manage leukemic variant of MCL? 

12:08 Is Watch-and-Wait reasonable in selected cases of nodal MCL with low Ki-67?

17:21 Overview on treatment of newly diagnosed MCL

19:03 Are all cytarabine-based regimens for MCL created equally?  

RCT of Autologous Transplantation in MCL: https://pubmed.ncbi.nlm.nih.gov/15591112/

21:39 In a world without upfront ibrutinib access as per TRIANGLE trial, do all fit patients with MCL need consolidation with auto-transplant? 

22:44 How to approach unfit patients with newly diagnosed MCL? 

RCT of bortezomib-based therapy (VR-CAP) in newly diagnosed MCL: https://pubmed.ncbi.nlm.nih.gov/25738670/

24:57 SHINE Trial-RCT of Ibrutinib plus BR in newly diagnosed MCL: https://pubmed.ncbi.nlm.nih.gov/35657079/

30:38 TRIANGLE Trial-RCT of upfront ibrutinib with or without auto-transplant in newly diagnosed MCL:

https://ashpublications.org/blood/article/134/Supplement_1/2816/423504

43:01: Does Allo-Transplant have any role in MCL?

44:08: What are the likely next breakthroughs in newly diagnosed MCL space?