SHR # 2777:: Is Fasting Making You Fat and Insulin Resistant - Joel Greene - I started fasting in 2007 after an interview with Dr. Mark McCarty who published the first study done on rats using the every-other-day protocol. It showed that periodic fasting elevated a variety of markers associated with improved aging and health. We've continued to discuss fasting on this show ever since. But something has changed. Like most things, we believe if a little is good a lot is better. There's a thin line between the hormetic effects of intermittent fasting and the biological perturbations of starvation. If you're someone who's tried fasting and it failed you, here's why. And to those of you just finding fasting, listen closely because you can save yourself a lot of grief.