More isn't always better. Our Landkmarks of OncoPharm series covers lessons learned from the ProMACE-CytaBOM regimen for NHL.
ProMACE-CytaBOM: https://www.annalsofoncology.org/article/S0923-7534(20)31592-1/pdf
RCT vs. CHOP (& others): https://www.nejm.org/doi/full/10.1056/NEJM199304083281404