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The Curbsiders Internal Medicine Podcast
#424 Hotcakes: Transfusion in Acute MI, COVID-19 Rebound after Paxlovid, Every-other-day Iron Revisited, Oral Phenylephrine Doesn’t Work, and Stop Correcting Serum Calcium
Jan 29, 2024
In this podcast, the hosts cover a range of intriguing topics including transfusion thresholds in acute MI, COVID-19 rebound after treatment with nirmatrelvir, the prevalence of iron deficiency, the ineffectiveness of oral phenylephrine, and the liberal vs restrictive transfusion strategy in MI. They also discuss challenges in transfusion decision making, highlight the unreliability of corrected calcium levels, and explore iron supplementation for anemia. A humorous introduction and calcium puns add entertainment to the episode.
56:07
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Quick takeaways
- The Mint trial showed that a liberal transfusion strategy may be beneficial for patients with type 1 MI, providing important insights into transfusion strategies in MI patients with anemia.
- The recommendation to remove oral phenylephrine from over-the-counter cold medications highlights the need for more effective alternatives in the cough and cold medication market.
Deep dives
The Mint Trial: Restrictive vs. Liberal Transfusion Strategy in MI and Anemia
The Mint trial aimed to determine whether a restrictive or liberal transfusion strategy is more effective in patients with acute myocardial infarction (MI) and anemia. The trial found that at 30 days, there was no significant difference in death or MI between the two groups. However, subgroup analysis showed a potential benefit of a liberal transfusion strategy in patients with type 1 MI. The study provides important insights into transfusion strategies in MI patients with anemia.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode