

Alcohol Use Disorder with Dr. Cummings
May 26, 2023
Dr. Michael Cummings, a respected psychiatrist and addiction expert from Loma Linda University, dives into the complexities of alcohol use disorder. He discusses the historical context and cultural significance of alcohol, along with genetic and psychological factors influencing addiction. Cummings highlights the intricate neurobiological circuits involved and the importance of pharmacological treatments like disulfiram and naltrexone. He emphasizes a comprehensive treatment approach that includes therapy and support, as well as the dangers of mixing illicit substances. It's a thought-provoking exploration of addiction.
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Alcohol's Historical and Social Impact
- Alcohol is mankind's oldest and most widely consumed intoxicant with a significant social cost.
- It often begins in adolescence with most users not developing problems, but a minority become addicted.
Genetics and Vulnerability to Alcohol Addiction
- Genetic vulnerability strongly influences risk for alcohol addiction, roughly 50% or more.
- Those with low sensitivity to alcohol and anhedonia are especially prone to addiction.
Epigenetic Influence on Alcohol Dependence
- Epigenetic mechanisms influence alcohol preference, demonstrated in animal studies.
- Promoter genes and microRNAs can increase offspring's risk of alcohol dependence.