a16z Podcast Journal Club: Using CRISPR to Prevent Coronavirus and Influenza Infection
May 15, 2020
Explore how CRISPR technology is revolutionizing the fight against viral infections like SARS-CoV and influenza. Discover innovative strategies that go beyond traditional vaccines and how they can target a range of viral strains. Delve into challenges in vaccine development and the potential of CRISPR as a game changer in pandemic preparedness. The discussion reveals the importance of treating pandemic readiness as a national defense priority, highlighting the need for advanced antiviral strategies.
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No Silver Bullets
- Drugs being developed for COVID-19 are not miracle cures.
- A vaccine or prophylactic is needed for the broader healthy population to return to normalcy.
Antibody-Dependent Enhancement
- Some viruses, like dengue, exhibit antibody-dependent enhancement (ADE), making vaccine development challenging.
- ADE could make secondary infections worse, potentially impacting COVID-19 vaccine development.
Vaccines vs. CRISPR Prophylactics
- Vaccines use dead virus parts to create antigens, stimulating the immune system.
- CRISPR-based prophylactics offer new functionality to tackle viruses directly, similar to antivirals.