Rheumnow Podcast
ACR24 PsA Topic Panel Advancing Care for Psoriatic Arthritis
Nov 27, 2024
Join Artie Kavanaugh, a rheumatologist from UC San Diego, and Quillen Connelly from Galway Clinic, as they delve into the intricate realm of psoriatic arthritis. They discuss the rising placebo response rates tied to socioeconomic factors and the urgent need for gender-specific research in treatment. Artie breaks down the potential of combination therapies, while Quillen shares insights on the durable effectiveness of bimikizumab. Together, they illuminate the latest advancements in diagnosis and treatment, providing a comprehensive overview for clinicians.
34:54
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Quick takeaways
- The rise in placebo response rates in psoriatic arthritis trials highlights the impact of socioeconomic factors on treatment perceptions and outcomes.
- Emerging research emphasizes the potential of combination therapies for psoriatic arthritis, balancing enhanced efficacy with concerns over safety in previously treated patients.
Deep dives
Placebo Response Trends in Psoriatic Arthritis
Research on the placebo response in psoriatic arthritis indicates a significant increase over time, reaching as high as 43% in some trials. This rise correlates with socioeconomic factors in various countries, suggesting that higher gross national income may lower placebo response rates. In developing nations, where access to care is limited, patients may perceive treatment effects differently, contributing to the observed increase. These findings emphasize the need for a deeper understanding of how socioeconomic elements influence clinical trial outcomes and the interpretation of therapeutic efficacy.
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