Healio Rheuminations

Whipple’s Disease: When Should a Rheumatologist Take a Whiff of Whipple’s?

May 20, 2020

47:26

This episode dives into the rare Whipple’s disease, focusing on the articular manifestations of this infectious masquerader and when a rheumatologist should consider it in the differential.

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Intro :20
In this episode :28
Background on the organism 5:25
An important point when making the diagnosis 7:48
Who gets infected? 8:55
What is Whipple’s disease? 11:48
This disease is fatal 15:53
A look at the joints 16:28
What happens when you give these patients immunosuppression? 26:36
How to diagnose 28:38
Summary so far 31:00

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Other organ manifestations of Whipple’s disease 32:08
Summary and take-home 44:36

Disclosure: Brown reports no relevant financial disclosures.

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References:

Bousbia S, et al. Emerg Infect Dis. 2010;16:258-63.

Chan RY, et al. Ophthalmology. 2001;108:2225-2231.

Dobbins 3rd WO, et al. Arthritis Rheum. 1987;30:102-105.

Durand DV, et al. Medicine (Baltimore). 1997;76:170-84.

Fenollar F, et al. BMC Infect Dis. 2011;11:171.

Feurle GE, et al. Eur J Clin Invest. 1979;9:385-389.

Geissdörfer W, et al. J Clin Microbiol. 2012;50:216-22.

Guérin A, et al. Elife. 2018;7:e32340.

Heffner DK. Lancet. 2007;370:738-9; author reply 739.