Renowned musician David Byrne joins Dana Carvey and David Spade on the podcast to discuss his career, puns, and dancing style. They also touch on dynamic pricing in concerts, therapy during the holidays, testing new material in comedy clubs, the effects of psilocybin and ketamine on brain health, and the use of therapies like psilocybin, LSD, and ketamine. The speakers talk about comfortable clothing, healthy dog food, attending comedy shows, political comedy, and their own art exhibits. They reflect on therapy experiences, express enjoyment of the interview, and discuss potential future projects.