Freely Filtered 014 COVID-19 Podcast No. 2

Loeb’s Laws of Medicine or Loeb’s Rules of Therapeutics

Robert Frederick Loeb (March 14, 1895-October 21, 1973) was a famous American Physician who provided some very simple common sense approach to treating patients know as:

1. If what you are doing is doing good, keep doing it.

2. If what you are doing is not doing good, stop doing it.

3. If you do not know what to do, do nothing.

4. Never make the treatment worse than the disease.

The last ‘law’ in present times is often replaced with:

“If at all possible, keep your patient out of the operating room.”

Or

“Above all, never let a surgeon get your patient.”

This is a decent reference for this: https://www.ncbi.nlm.nih.gov/books/NBK13258/

Dr. Glaucomflecken gives some tips for attending trying to go back to the ICU: https://twitter.com/DGlaucomflecken/status/1238954558140772354?s=20

Francis Deng and going back to become an internist: https://twitter.com/francisdeng/status/1245475268158009349?s=20

JCI article on using convalescent serum for treating disease: https://www.jci.org/articles/view/138003

Human trial of convalescent serum from JAMA: https://jamanetwork.com/journals/jama/fullarticle/2763983 It works! (in uncontrolled, observational trials)

Monkeys develop protective antibodies: https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1

Time course for antibodies and viral clearance in SARS-CoV2 from Nature: https://www.nature.com/articles/s41586-020-2196-x

Peripheral blood monocyte proeonomics: https://www.biorxiv.org/content/10.1101/2020.03.31.019216v1.full.pdf

Cytokine storm in the New York Times. Check mate Rheumatologists: https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html

Dr. Anthony Chang and Thrombi on COVID biopsies: https://twitter.com/ChangUCanSpare/status/1240686922332160001?s=20

ASN April 2 Webinar on dialysis and COVID-19 with Anitha Vijayan (among others): https://www.asn-online.org/ntds/resources/Webcast_2020_04_02_COVID-19.mp4

UK data on length of ventilatory support (ICNARC): https://t.co/WB1ZnODRFF?amp=1

Swap forgot Michele Mokrzycki’s name. Her name is Michele.

Samira’s elementary school shampoo: https://www.influenster.com/reviews/pert-plus-classic-clean-2-in-1-shampoo-conditioner

Prolonged Intermittent Renal Replacement Therapy (PIRRT): https://www.ncbi.nlm.nih.gov/pubmed/27113696

MDCalc COVID-Resource Center: https://www.mdcalc.com/covid-19

Acute PD for COVID-19 is discussed in this article from CJASN: https://cjasn.asnjournals.org/content/early/2020/04/03/CJN.03750320

PD for AKI, the experience from Brazil https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525422/

The lead author, Daniela Ponce is really the world authority on PD and AKI: https://www.ncbi.nlm.nih.gov/pubmed/?term=Ponce%20D%5BAuthor%5D&cauthor=true&cauthor_uid=22641732

NEJM ACE2 review article that Matt didn’t read or peer review: https://www.nejm.org/doi/full/10.1056/NEJMsr2005760

NephJC COVID site: http://www.nephjc.com/covid19