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Alternating between sitting and standing while using a standing desk is crucial for minimizing discomfort and promoting health. Research suggests that for every one to two hours spent sitting, one hour should be allocated to standing to avoid issues like lower back pain and varicose veins. The optimal approach involves changing positions every 30 to 60 minutes to maintain comfort and energy levels. This balance not only aids in reducing the physical stress associated with prolonged sitting or standing but also enhances overall productivity.