332: Pfizer's new R&D head, a VC deep-dive, and a new FDA commissioner?
Nov 21, 2024
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Bruce Booth, a partner at Atlas Venture, shares expert insights on biotech trends and innovation. He discusses his annual review report, emphasizing how China's growing influence shapes the industry. The potential implications of a new FDA commissioner under a Trump administration are explored, highlighting challenges in drug approvals. Booth also reflects on investor sentiment amid political changes and the evolving landscape of pharmaceutical leadership, making predictions for the future of biotech and healthcare.
Marty McCary's candidacy for FDA commissioner could signify a transformative shift in the agency's approach to drug approvals and public health.
Chris Boshoff's appointment as Pfizer's new R&D head reflects a strategic internal promotion as the company faces challenges in research performance.
Deep dives
Potential FDA Leadership Change
Marty McCary is emerging as a leading candidate for the new FDA commissioner position, indicating a potential shift in leadership within the agency. Known for his pragmatic approach, McCary has garnered attention for both defending and critiquing policies, particularly around COVID-19 vaccines. His relationship with the current FDA leadership raises questions about future collaboration if he is appointed. This potential appointment could signify a transformation in the FDA's approach to drug approvals and public health initiatives.
Pfizer's New R&D Chief
Chris Boshoff has been appointed as the new head of research and development at Pfizer, succeeding Michael Dolston. Boshoff's internal move from leading the oncology division highlights a strategic decision to promote from within amidst pressures concerning Pfizer's recent R&D performance. There are mixed opinions on the effectiveness of this appointment, as stakeholders ponder whether an external candidate might have injected fresh perspectives into the company's research strategy. The effectiveness of Boshoff's leadership will become clearer as he navigates Pfizer's future drug development efforts.
Ned Sharpless's New Venture
Ned Sharpless is partnering with biotech entrepreneur Ned David to launch Jupiter BioVentures, a venture fund focused on launching multiple projects simultaneously. This venture aims to streamline the pharmaceutical development process by encouraging the early termination of failing projects. With initial seed funding of around $70 million, they will prioritize promising candidates in areas such as CAR-T therapy and treatments for rare diseases. By addressing the tendency to cling to unpromising projects, this initiative aims to enhance overall efficiency in drug development.
Year in Review Insights
Bruce Booth's annual year-in-review report reveals significant trends in the biotech and pharmaceutical industries, including a focus on obesity drugs and increasing innovation from China. The rapid rise in popularity and effectiveness of obesity medications marks a notable transformation in drug development priorities. Additionally, the report highlights China's growing role as a source of valuable drug innovation, which presents both opportunities and challenges in the current geopolitical climate. The implications of these changes may affect future investments and collaborations in the biotech sector.
Atlas Venture Partner Bruce Booth joins the podcast to discuss his annual year in review report, the influence of China, and what the new Trump administration might mean for innovation. Adam and Allison also recap the latest news in the life sciences, including a new science chief at Pfizer, a new job for Ned Sharpless, and the ongoing presidential appointments.
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