In this conversation with EdUp Provost host Dr. Gregor Thuswaldner, Dr. Christian Busch discusses the concept of serendipity in leadership, emphasizing how individuals and organizations can cultivate a mindset to recognize and act on unexpected opportunities. He explores the importance of trust, clarity, and a culture of psychological safety in fostering innovation and resilience within academic institutions. The discussion also highlights the significance of interdisciplinary collaboration, diversity, and overcoming mental shortcuts to create an adaptable academic culture. Dr. Busch provides practical strategies for academic leaders to reframe setbacks as learning opportunities and encourages the development of environments that promote meaningful connections among faculty and students. Takeaways • Serendipity is about active luck that we create ourselves. • Cultivating a serendipity mindset is essential for leadership. • Reframing setbacks can foster innovation and resilience. • Creating a culture of psychological safety encourages open communication. • Building connections between unrelated ideas can lead to breakthroughs.